Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0004096
Disease: Asthma
Asthma 		0.500 GeneticVariation LHGDN IL-10(-1082(G-->A)) G/G and TNF-alpha-308(G-->A) G/G may be a contributing factor in susceptibility as well as severity of asthma among Egyptian children. 18534084

2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.400 Biomarker LHGDN Role of TNF-alpha produced by nonantigen-specific cells in a fulminant hepatitis mouse model. 19109170

2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 AlteredExpression LHGDN Peripheral cytokines profile in Parkinson's disease. 18678243

2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated 		0.300 GeneticVariation LHGDN The G-308A polymorphism of the TNF-alpha gene does not predict changes in cardiac function in response to medical therapy for idiopathic dilated cardiomyopathy. 18997986

2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.300 AlteredExpression LHGDN Increase of CD4+TNF{alpha}+IL-2-T cells in cerebrospinal fluid of multiple sclerosis patients. 18755820

2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0019158
Disease: Hepatitis
Hepatitis 		0.100 Biomarker LHGDN Role of TNF-alpha produced by nonantigen-specific cells in a fulminant hepatitis mouse model. 19109170

2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 AlteredExpression LHGDN Defects in TNFalpha signalling pathways rather than distribution of TNF receptors (TNFRs) probably explain the enhanced apoptosis in SLE. 19110660

2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0520679
Disease: Sleep Apnea, Obstructive
Sleep Apnea, Obstructive 		0.100 AlteredExpression LHGDN Obstructive sleep apnoea syndrome is associated with enhanced sub-clinical inflammation and asymmetric dimethyl-arginine levels in hypertensives. 18685607

2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0002390
Disease: Extrinsic allergic alveolitis
Extrinsic allergic alveolitis 		0.040 Biomarker LHGDN The levels of IL-12, IL-18, and TNF-alpha showed no difference between patients with acute and chronic HP. 19230467

2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0016978
Disease: gallbladder neoplasm
gallbladder neoplasm 		0.010 GeneticVariation LHGDN Do TNFA -308 G/A and IL6 -174 G/C gene polymorphisms modulate risk of gallbladder cancer in the north Indian population? 18260730

2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 GeneticVariation LHGDN Rheumatoid arthritis patients showed high TNFalpha mRNA expression (1.33-fold). 18797411

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 Biomarker LHGDN BAT1 promoter polymorphism is associated with rheumatoid arthritis susceptibility. 18381799

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 AlteredExpression LHGDN Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor. 18668547

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 Biomarker LHGDN Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures. 19017992

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 GeneticVariation LHGDN Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population. 17562093

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 Biomarker LHGDN Rheumatoid arthritis, periodontal disease and coronary artery disease. 17763921

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.600 Biomarker LHGDN Because UC patients are at increased risk for developing colorectal cancer (CRC), we investigated if there was an association between SNPs in the promoter of the TNF-alpha gene and UC-CRC. 18289203

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018801
Disease: Heart failure
Heart failure 		0.600 AlteredExpression LHGDN Comparing Type D personality and older age as correlates of tumor necrosis factor-alpha dysregulation in chronic heart failure. 18068948

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker LHGDN In conclusion, our findings show that plasma tHcy is a determinant of TNF-alpha in hypertension and that obesity or a history of vascular events aggravates inflammation in patients with hypertension. 18093792

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0021368
Disease: Inflammation
Inflammation 		0.600 Biomarker LHGDN The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events: Implication in periodontal inflammation. 18543247

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0021368
Disease: Inflammation
Inflammation 		0.600 AlteredExpression LHGDN Proinflammatory cytokines seem to be only partly involved in the pathophysiology of CRPS1, as indicated by the lack of coherence between TNF-alpha and IL-6 levels and the signs and symptoms of inflammation and disease duration. 18055234

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.600 GeneticVariation LHGDN Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk. 18698679

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0004096
Disease: Asthma
Asthma 		0.500 GeneticVariation LHGDN The tumour necrosis factor-alpha gene nucleotide -308 polymorphism is associated with a moderately increased risk of asthma and bronchial hyperresponsiveness, but not with atopy. 18385169

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0004096
Disease: Asthma
Asthma 		0.500 GeneticVariation LHGDN The TNF-alpha promoter polymorphism (-308G/A) may be associated with asthma susceptibility and BHR in Korean children with asthma. 18341619

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.400 Biomarker LHGDN Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis. 18316608

2008